Low-dose leptin infusion in the fourth ventricle of rats enhances the response to third-ventricle leptin injection
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چکیده
منابع مشابه
Effects of intra-fourth ventricle injection of crocin on capsaicin-induced orofacial pain in rats
Objectives: Crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. In the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. The contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. Materials and Methods: A guide cann...
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Previously, we reported that low-dose leptin infusions into the fourth ventricle produced a small but significant increase in body fat. These data contrast with reports that injections of higher doses of leptin into the fourth ventricle inhibit food intake and weight gain. In this study, we tested whether exogenous leptin in the fourth ventricle opposed or contributed to weight loss caused by t...
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The authors review the main technical approaches to the third ventricle, the most common surgical indications and their results. The traditional open techniques are characterized by low rate of residual lesion and risk, although low, epilepsy postoperatively. Endoscopic techniques has gained wide acceptance by patients and neurosurgeons because of the low rates of complications and reduced hosp...
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Desai BN, Harris RB. Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus. Am J Physiol Endocrinol Metab 308: E351–E361, 2015. First published December 30, 2014; doi:10.1152/ajpendo.00501.2014.—Leptin receptors (ObRs) in the forebrain and hindbrain have been independently recognized as important mediators of leptin responses. We recently used low-dose leptin infusion...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2017
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00052.2017